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Accelerated stem cell attachment to ultrafine grained titanium

Paper ID Volume ID Publish Year Pages File Format Full-Text
1000 70 2011 7 PDF Available
Title
Accelerated stem cell attachment to ultrafine grained titanium
Abstract

Commercial purity titanium with an average grain size in the low sub-micron range was produced by equal channel angular pressing (ECAP). Attachment of human bone marrow-derived mesenchymal stem cells (hMSCs) to the surface of conventional coarse grained and ECAP-modified titanium was studied. It was demonstrated that the attachment and spreading of hMSCs in the initial stages (up to 24 h) of culture was enhanced by grain refinement. Surface characterization by a range of techniques showed that the main factor responsible for the observed acceleration of hMSC attachment and spreading on titanium due to grain refinement in the bulk is the attendant changes in surface topography on the nanoscale. These results indicate that, in addition to its superior mechanical properties, ECAP-modified titanium possesses improved biocompatibility, which makes it to a potent candidate for applications in medical implants.

Keywords
Mesenchymal stem cell; Titanium; Cell adhesion; Cell spreading; Nanotopography
First Page Preview
Accelerated stem cell attachment to ultrafine grained titanium
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 900–906
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering