fulltext.study @t Gmail

Engineering thermoresponsive polymeric nanoshells

Paper ID Volume ID Publish Year Pages File Format Full-Text
10008 658 2009 8 PDF Available
Title
Engineering thermoresponsive polymeric nanoshells
Abstract

This study describes a family of hollow nanoscale constructs able to display a large and reversible change in size, within a narrow temperature interval. These thermoresponsive nanostructures are generated by crosslinking functionalized amphiphilic molecules, such as poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO) triblocks, while constrained to their particular micellar configuration. This contribution focuses on the generation of these supramolecular architectures, by intra-micellarly crosslinking PEO–PPO–PEO dimethacrylate amphiphiles, and investigates their temperature-dependent dimensional behavior. Spherical nanoshells displaying a 200 nm diameter at 15 °C, shrink sharply around 28 °C, generating a compact structure of approximately 40 nm at body temperature. Thermoresponsive nanotubes were created by generating them from rod-like micelles at higher temperatures. By varying the composition of the triblock, the transition temperature can be fine tuned, from around 25 °C to slightly above body temperature. Also, the nanoshells were rendered biodegradable by incorporating aliphatic oligoesters into their structure. Numerous applications for these nanostructures are foreseen in various biomedical areas, such as in drug and gene delivery, in the tissue engineering and in the biosensors field.

Keywords
Thermoresponsive polymer; Nanoparticle; Degradation; Crosslinking; Pluronics
First Page Preview
Engineering thermoresponsive polymeric nanoshells
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 19, July 2009, Pages 3289–3296
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us