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Modulating cellular adhesion through nanotopography

Paper ID Volume ID Publish Year Pages File Format Full-Text
10035 659 2010 7 PDF Available
Modulating cellular adhesion through nanotopography

Cellular adhesion is a fundamental process in the development of scaffolds for tissue engineering; in the design of biosensors and in preparing antibacterial substrates. A theoretical model is presented for predicting the strength of cellular adhesion to originally inert surfaces as a function of the substrate topography, accounting for both specific (ligand–receptor) and non-specific interfacial interactions. Three regimes have been identified depending on the surface energy (γ) of the substrate: for small γ, any increase in roughness is detrimental to adhesion; for large γ, an optimal roughness exists that maximizes adhesion; and for intermediate γ, surface roughness has a minor effect on adhesion. The results presented are in qualitative agreement with several experimental observations and can capture the long-term equilibrium configuration of the system. The model proposed supports the notion for rationally designing substrates where topography and physico-chemical properties are tailored to favour cellular proliferation whilst repelling bacterial adhesion.

Cellular adhesion; Nanotopography; Surface energy; Mathematical modelling
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Modulating cellular adhesion through nanotopography
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 1, January 2010, Pages 173–179
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Physical Sciences and Engineering Chemical Engineering Bioengineering