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Clay enriched silk biomaterials for bone formation

Paper ID Volume ID Publish Year Pages File Format Full-Text
1004 71 2011 6 PDF Available
Title
Clay enriched silk biomaterials for bone formation
Abstract

The formation of silk protein/clay composite biomaterials for bone tissue formation is described. Silk fibroin serves as an organic scaffolding material offering mechanical stability suitable for bone-specific uses. Clay montmorillonite (Cloisite® Na+) and sodium silicate are sources of osteoinductive silica-rich inorganic species, analogous to bioactive bioglass-like bone repair biomaterial systems. Different clay particle–silk composite biomaterial films were compared with silk films doped with sodium silicate as controls for the support of human bone marrow derived mesenchymal stem cells in osteogenic culture. The cells adhered to and proliferated on the silk/clay composites over 2 weeks. Quantitative real time polymerase chain reaction analysis revealed increased transcript levels for alkaline phosphatase, bone sialoprotein, and collagen type 1 osteogenic markers in the cells cultured on the silk/clay films in comparison with the controls. Early evidence of bone formation based on collagen deposition at the cell–biomaterial interface was also found, with more collagen observed for the silk films with higher contents of clay particles. The data suggest that silk/clay composite systems may be useful for further study for bone regenerative needs.

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Keywords
Silk; Clay; Montmorillonite; Stem cells; Osteogenesis
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Clay enriched silk biomaterials for bone formation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 8, August 2011, Pages 3036–3041
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us