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Functionalized injectable hydrogels for controlled insulin delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
10058 661 2008 8 PDF Available
Title
Functionalized injectable hydrogels for controlled insulin delivery
Abstract

The concept of this research is using poly(β-amino ester) (PAE) as a duo-functional group for synthesis of the novel sensitive injectable hydrogel for controlled drug/protein delivery. Firstly, PAE made of 1,4-butanediol diacrylate and 4,4′-trimethylene dipiperidine is used as a pH-sensitive moiety to conjugat to the temperature-sensitive biodegradable triblock copolymer of poly(ethylene glycol)–poly(ɛ-caprolactone) (PCL–PEG–PCL) to manufacture pH/temperature-sensitive injectable hydrogel of pentablock copolymer PAE–PCL–PEG–PCL–PAE. Furthermore, the cationic nature of PAE is used as the second function to make the ionic complexes with anionic biomolecule loaded into the hydrogel such as insulin. As a result, the release of drug/protein from this hydrogel device can be controlled by the degradation of copolymer. Sol–gel phase transition behavior of PAE–PCL–PEG–PCL–PAE block copolymer was investigated; the results showed that the aqueous media of the pentablock copolymer changed from a sol to a gel phase with increasing temperature and pH. The effect of anionic biomolecule such as insulin on sol–gel phase transition, degradation of the complex gel of the material with insulin was studied in vitro. Then the schematic of the ionic complexes between positive charges in PAE and the negatively charges in protein was simulated. In addition, the mechanism of controlled release behavior of insulin from the complex gel was supposed, which includes the chemically-controlled and diffusion-controlled stages. To prove the simulations, the cumulative release of the protein from the complex gel was investigated in vitro with different methods. Furthermore, the pharmacokinetic release of insulin from the complex gel in vivo on male Sprague-Dawley (SD) rats was compared with that from triblock copolymer hydrogel of PCL–PEG–PCL.

Keywords
pH/temperature-sensitive; Hydrogel; Insulin delivery; Controlled release
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Functionalized injectable hydrogels for controlled insulin delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 16, June 2008, Pages 2527–2534
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us