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Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Paper ID Volume ID Publish Year Pages File Format Full-Text
10060 661 2008 8 PDF Available
Title
Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
Abstract

Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

Keywords
Magnetic nanoparticle; Fluorescence; Nanohybrid; Cancer; Cetuximab
First Page Preview
Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 16, June 2008, Pages 2548–2555
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering