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Bone formation at the surface of low modulus Ti–7.5Mo implants in rabbit femur

Paper ID Volume ID Publish Year Pages File Format Full-Text
10067 662 2007 8 PDF Available
Title
Bone formation at the surface of low modulus Ti–7.5Mo implants in rabbit femur
Abstract

The biocompatibility of the Ti–7.5Mo alloy was examined, because the alloy has a high-strength/modulus ratio and thus is a potential candidate for orthopedic applications. Cell viability assay using 3T3 cells revealed that the Ti–7.5Mo did not induce apparent cell death, when the cells were grown on disks made of the alloy or incubated with the alloy-conditioned medium at 37 or 72 °C for 24–72 h. The Ti–6Al–4V alloy was used as a control and did not cause apparent cell death either. Moreover, pins of 6 mm long and 2 mm in diameter of Ti–7.5Mo and Ti–6Al–4V were implanted into the left and right rabbit femurs, respectively, for 6, 12 and 26 weeks. New bone tissue grew to surround the pins, which spanned cortical and marrow regions, as shown by toluidine blue-stained bone sections of the three time points. Strikingly, the amount of new bone encircling the Ti–7.5Mo implant was approximate two-folds of that at Ti–6Al–4V by 26 weeks post-implantation. This facilitation of bone formation could be associated with the unique properties, such as a low modulus and the composition of Mo, of the Ti–7.5Mo.

Keywords
Cell viability; Implantation to femur; Bone growth; Bone marrow; Bioabsorption
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Bone formation at the surface of low modulus Ti–7.5Mo implants in rabbit femur
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 16, June 2007, Pages 2582–2589
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us