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Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer

Paper ID Volume ID Publish Year Pages File Format Full-Text
10085 663 2009 7 PDF Available
Title
Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer
Abstract

HER2 detection is important for breast cancer (BC) treatment and prognosis, but the detection methods currently used have some disadvantages. Quantum dots (QDs)-based probes provide a potentially important new method for HER2 detection in clinical practice. This potential is examined in this paper. A QDs HER2 probe kit and QDs image acquisition and analysis software were developed and applied to 94 clinical samples of BC. Compared to conventional immunohistochemistry techniques, this method provided a superior accurate and sensitive method for the detection of HER2 in clinical breast cancer diagnosis.

Keywords
Quantum dots; Breast cancer; HER2; Immunohistochemistry; Fluorescence in situ hybridization
First Page Preview
Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 15, May 2009, Pages 2912–2918
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering