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Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
10086 663 2009 10 PDF Available
Title
Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging
Abstract

Iron oxide nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at tissue, cellular or even molecular levels. In this study, manganese doped superparamagnetic iron oxide (Mn-SPIO) nanoparticles were used to form ultrasensitive MRI contrast agents for liver imaging. Hydrophobic Mn-SPIO nanoparticles are synthesized in organic phase and then transferred into water with the help of block copolymer mPEG-b-PCL. These Mn-SPIO nanoparticles are self-assembled into small clusters (mean diameter ≈ 80 nm) inside micelles as revealed by transmission electron microscopy. Mn-SPIO nanoparticles inside micelles decrease PCL crystallization temperatures, as verified from differential scanning calorimetry and Fourier transform infrared spectroscopy. The Mn-SPIO based nanocomposites are superparamagnetic at room temperature. At the magnetic field of 1.5 T, Mn-SPIO nanoparticle clustering micelles have a T2 relaxivity of 270 (Mn + Fe) mM−1 s−1, which is much higher than single Mn-SPIO nanoparticle containing lipid–PEG micelles. This clustered nanocomposite has brought significant liver contrast with signal intensity changes of −80% at 5 min after intravenous administration. The time window for enhanced-MRI can last about 36 h with obvious contrast on liver images. This sensitive MRI contrast agent may find applications in identification of small liver lesions, evaluation of the degree of liver cirrhosis, and differential diagnosis of other liver diseases.

Keywords
Manganese ferrite; Block copolymer; MRI; Mouse liver; Contrast agent
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Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 15, May 2009, Pages 2919–2928
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us