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Shield effect of silicate on adsorption of proteins onto silicon-doped hydroxyapatite (100) surface

Paper ID Volume ID Publish Year Pages File Format Full-Text
10131 666 2008 10 PDF Available
Title
Shield effect of silicate on adsorption of proteins onto silicon-doped hydroxyapatite (100) surface
Abstract

Protein adsorption–desorption on nanoscale surface plays a key role in biomaterials, cell adhesion, biosensors, biofuel cells and biomineralization. Silicate-substituted hydroxyapatite (SiHA) is one of the most interesting bioceramics in the field of bioactive hard tissue implants. In this paper, the adsorption–desorption behaviors of leucine-rich amelogenin protein (LRAP) on a series of SiHA (100) surfaces were investigated using the molecular dynamics (MD), steered molecular dynamics (SMD) simulations and density functional theory (DFT) calculations. It was found that the silicate ions on SiHA (100) surface cause a shield effect, which was composed of the charge repulsion and the steric hindrance of silicates. These findings suggest that surface engineering technologies can be potentially used to directly control/manufacture the nanoscale surface texture and the composition of material surfaces, thereby to mediate the interaction of proteins with biomaterials.

Keywords
Silicate-substituted hydroxyapatite (SiHA); Leucine-rich amelogenin protein (LRAP); Steered molecular dynamics (SMD); Shield effect; Adsorption
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 15, May 2008, Pages 2423–2432
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us