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Bulk and interface investigations of scaffolds and tissue-engineered bones by X-ray microtomography and X-ray microdiffraction

Paper ID Volume ID Publish Year Pages File Format Full-Text
10145 667 2007 20 PDF Available
Title
Bulk and interface investigations of scaffolds and tissue-engineered bones by X-ray microtomography and X-ray microdiffraction
Abstract

This review is presented of recent investigations concerning the structure of ceramic scaffolds and tissue-engineered bones and focused on two techniques based on X-ray radiation, namely microtomography (microCT) and microdiffraction. Bulk 3D information, with micro-resolution, is mainly obtained by microCT, whereas microdiffraction provides useful information on interfaces to the atomic scale, i.e. of the order of the nanometer. Since most of the reported results were obtained using synchrotron radiation, a brief description of the European Synchrotron Radiation Facility (ESRF) is presented, followed by a description of the two techniques. Then examples of microstructural investigations of scaffolds are reported together with studies on bone architecture. Finally, studies on ex vivo tissue-engineered bone and on bone microstructure in vivo are presented.

Keywords
Bone tissue engineering; Bone marrow; Scaffold; Calcium phosphate; Image analysis; XRD (X-ray diffraction)
First Page Preview
Bulk and interface investigations of scaffolds and tissue-engineered bones by X-ray microtomography and X-ray microdiffraction
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 15, May 2007, Pages 2505–2524
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering