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In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy

Paper ID Volume ID Publish Year Pages File Format Full-Text
10154 668 2009 12 PDF Available
Title
In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy
Abstract

Magnesium has shown potential application as a bio-absorbable biomaterial, such as for bone screws and plates. In order to improve the surface bioactivity, a calcium phosphate was coated on a magnesium alloy by a phosphating process (Ca–P coating). The surface characterization showed that a porous and netlike CaHPO4·2H2O layer with small amounts of Mg2+ and Zn2+ was formed on the surface of the Mg alloy. Cells L929 showed significantly good adherence and significantly high growth rate and proliferation characteristics on the Ca–P coated magnesium alloy (p < 0.05) in in-vitro cell experiments, demonstrating that the surface cytocompatibility of magnesium was significantly improved by the Ca–P coating. In vivo implantations of the Ca–P coated and the naked alloy rods were carried out to investigate the bone response at the early stage. Both routine pathological examination and immunohistochemical analysis demonstrated that the Ca–P coating provided magnesium with a significantly good surface bioactivity (p < 0.05) and promoted early bone growth at the implant/bone interface. It was suggested that the Ca–P coating might be an effective method to improve the surface bioactivity of magnesium alloy.

Keywords
Magnesium; Calcium phosphate coating; Bioactivity; Biocompatility; Bone; in vitro test
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In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 8, March 2009, Pages 1512–1523
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us