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The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
10160 668 2009 10 PDF Available
Title
The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering
Abstract

In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.

Keywords
Bone healing; Hydrogel; Degradation; In vivo test; Fluorescence; Siloxane
First Page Preview
The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 8, March 2009, Pages 1568–1577
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering