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The role of the silicatein-α interactor silintaphin-1 in biomimetic biomineralization ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
10168 668 2009 9 PDF Available
Title
The role of the silicatein-α interactor silintaphin-1 in biomimetic biomineralization ☆
Abstract

Biosilicification in sponges is initiated by formation of proteinaceous filaments, predominantly consisting of silicateins. Silicateins enzymatically catalyze condensation of silica nanospheres, resulting in symmetric skeletal elements (spicules). In order to create tailored biosilica structures in biomimetic approaches it is mandatory to elucidate proteins that are fundamental for the assembly of filaments. Silintaphin-1 is a core component of modularized filaments and also part of a spicule-enfolding layer. It bears no resemblance to other proteins, except for the presence of an interaction domain that is fundamental for its function as scaffold/template. In the presence of silicatein silintaphin-1 facilitates the formation of in vitro filaments. Also, it directs the assembly of γ-Fe2O3 nanoparticles and surface-immobilized silicatein to rod-like biocomposites, synthetic spicules. Thus, silintaphin-1 will contribute to biomimetic approaches that pursue a controlled formation of patterned biosilica-based materials. Its combination with γ-Fe2O3 nanoparticles and immobilized silicatein will furthermore inspire future biomedical applications and clinical diagnostics.

Keywords
Biosilicification; Silicatein interactor; Silintaphin-1; Sponges; γ-Fe2O3 nanoparticles
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The role of the silicatein-α interactor silintaphin-1 in biomimetic biomineralization ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 8, March 2009, Pages 1648–1656
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us