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Silicon-substituted calcium phosphates – A critical view ☆☆☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
10171 669 2009 4 PDF Available
Title
Silicon-substituted calcium phosphates – A critical view ☆☆☆
Abstract

Nowadays, the scientific community widely accepts the statement that silicon-substituted calcium phosphates have better biological properties compared to pure calcium phosphates. For example, a review published in this journal in 2007 started with the sentence “Silicon (Si) substitution in the crystal structures of calcium phosphate (CaP) ceramics such as hydroxyapatite (HA) and tricalcium phosphate (TCP) generates materials with superior biological performance to stoichiometric counterparts” [1]. A critical look at published articles demonstrates that this sentence is controversial and somehow misleading, because there is no experimental evidence that Si ions are released from Si-substituted calcium phosphates at therapeutic concentrations, and because there is no study linking the improved biological performance of Si-substituted calcium phosphates to Si release. The aim of this article is to explain this statement in more details.

Keywords
Calcium phosphate; Silicon; Bioactivity; Hydroxyapatite; In vitro
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Silicon-substituted calcium phosphates – A critical view ☆☆☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 32, November 2009, Pages 6403–6406
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us