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Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue

Paper ID Volume ID Publish Year Pages File Format Full-Text
10185 670 2008 11 PDF Available
Title
Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue
Abstract

The myocardial tissue lacks significant intrinsic regenerative capability to replace the lost cells. Therefore, the heart is a major target of research within the field of tissue engineering, which aims to replace infarcted myocardium and enhance cardiac function. The primary objective of this work was to develop a biocompatible, degradable and superelastic heart patch from poly(glycerol sebacate) (PGS). PGS was synthesised at 110, 120 and 130 °C by polycondensation of glycerol and sebacic acid with a mole ratio of 1:1. The investigation was focused on the mechanical and biodegrading behaviours of the developed PGS. PGS materials synthesised at 110, 120 and 130 °C have Young's moduli of 0.056, 0.22 and 1.2 MPa, respectively, which satisfy the mechanical requirements on the materials applied for the heart patch and 3D myocardial tissue engineering construction. Degradation assessment in phosphate buffered saline and Knockout™ DMEM culture medium has demonstrated that the PGS has a wide range of degradability, from being degradable in a couple of weeks to being nearly inert. The matching of physical characteristics to those of the heart, the ability to fine tune degradation rates in biologically relevant media and initial data showing biocompatibility indicate that this material has promise for cardiac tissue engineering applications.

Keywords
Myocardial tissue engineering; Heart patch; Poly(glycerol sebacate); Mechanical property; Degradation; Biocompatibility
First Page Preview
Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 1, January 2008, Pages 47–57
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering