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The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages

Paper ID Volume ID Publish Year Pages File Format Full-Text
10219 672 2009 9 PDF Available
Title
The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages
Abstract

Due to advances in stem cell biology, embryonic stem (ES) cells can be induced to differentiate into a particular mature cell lineage when cultured as embryoid bodies. Although transplantation of ES cells-derived neural progenitor cells has been demonstrated with some success for either spinal cord injury repair in small animal model, control of ES cell differentiation into complex, viable, higher ordered tissues is still challenging. Mouse ES cells have been induced to become neural progenitors by adding retinoic acid to embryoid body cultures for 4 days. In this study, we examine the use of electrospun biodegradable polymers as scaffolds not only for enhancing the differentiation of mouse ES cells into neural lineages but also for promoting and guiding the neurite outgrowth. A combination of electrospun fiber scaffolds and ES cells-derived neural progenitor cells could lead to the development of a better strategy for nerve injury repair.

Keywords
Embryonic stem cell; Electrospinning; Nanofibers; Poly(ɛ-caprolactone); Differentiation; Nerve repair
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The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 3, January 2009, Pages 354–362
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us