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Elastin-mimetic protein polymers capable of physical and chemical crosslinking

Paper ID Volume ID Publish Year Pages File Format Full-Text
10225 672 2009 14 PDF Available
Title
Elastin-mimetic protein polymers capable of physical and chemical crosslinking
Abstract

We report the synthesis of a new class of recombinant elastin-mimetic triblock copolymer capable of both physical and chemical crosslinking. These investigations were motivated by a desire to capture features unique to both physical and chemical crosslinking schemes so as to exert optimal control over a wide range of potential properties afforded by protein-based multiblock materials. We postulated that by chemically locking a multiblock protein assembly in place, functional responses that are linked to specific domain structures and morphologies may be preserved over a broader range of loading conditions that would otherwise disrupt microphase structure solely stabilized by physical crosslinking. Specifically, elastic modulus was enhanced and creep strain reduced through the addition of chemical crosslinking sites. Additionally, we have demonstrated excellent in vivo biocompatibility of glutaraldehyde treated multiblock systems.

Keywords
Recombinant elastin-mimetic; Protein polymer; Mechanical testing; In vivo biocompatibility
First Page Preview
Elastin-mimetic protein polymers capable of physical and chemical crosslinking
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 3, January 2009, Pages 409–422
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering