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A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
10249 675 2007 7 PDF Available
Title
A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue ☆
Abstract

In designing scaffolds for tissue regeneration, the principal objective is to recapitulate extracellular matrix (ECM) function in a temporally coordinated and spatially organised structure. A key issue is to encode required biological signals within the scaffold so that all aspects of cell response—adhesion and migration, proliferation and phenotype choice—can be controlled. In achieving this objective nanotechnology, bottom-up design approach and solid free-form fabrication (SFF) will play key roles, along with self-assembly processes. For scaffold materials, there must be the correct balance between architectural features notably, porosity and chemical, physical and biological properties. This paper reviews the main achievements in biomaterials design and the future challenges.

Keywords
Scaffold; Polymer; Tissue engineering; Tissue analogue; Molecular signals
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A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 34, December 2007, Pages 5093–5099
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us