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Group analysis of regulation of fibroblast genome on low-adhesion nanostructures

Paper ID Volume ID Publish Year Pages File Format Full-Text
10311 679 2007 9 PDF Available
Title
Group analysis of regulation of fibroblast genome on low-adhesion nanostructures
Abstract

Nanotopographical material modification represents a possible way of producing surfaces that influence cellular adhesion for biomaterials purposes. Here, two low-adhesion surfaces are studied with human genome microarrays (120 nm diameter pits produced by electron beam lithography and 11 nm high columns produced by colloidal lithography). In order to present the large numbers of results produced in a succinct and easy to understand manner, two types of recent bioinformatics methods were used; iterative group analysis and Ingenuity pathway analysis. These methods allowed the easy comparison of the nanomaterials and showed large-scale changes in areas of extracellular matrix, cell signalling and inflammation. The results demonstrate that whilst modes of cellular response to low-adhesion materials are similar, the more adhesion is reduced, the further ‘shut-down’ of critical cellular activities is observed. We also feel that the analysis used could be of interest to biomaterials scientists looking for easy ways to display microarray data efficiently.

Keywords
Nanotopography; Nanobioscience; Bioinformatics; Fibroblast; Genomics
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Group analysis of regulation of fibroblast genome on low-adhesion nanostructures
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 10, April 2007, Pages 1761–1769
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us