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Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons

Paper ID Volume ID Publish Year Pages File Format Full-Text
10327 679 2007 8 PDF Available
Title
Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons
Abstract

This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles.

Keywords
Adult spinal cord neurons; Auto-catalytic; Cerium oxide; Nanoparticle; Neuroprotection; Nerve regeneration
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Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 10, April 2007, Pages 1918–1925
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us