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Computational modelling of cell spreading and tissue regeneration in porous scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
10328 679 2007 15 PDF Available
Title
Computational modelling of cell spreading and tissue regeneration in porous scaffolds
Abstract

Improved biological and mechanical functionality of musculoskeletal tissue-engineered constructs is required for clinical application, which can only be achieved by comprehensive multidisciplinary research. This review focuses on the contribution of computational modelling as a framework for obtaining an integrated understanding of key processes, which include: nutrient transport and utilization, matrix formation, cell population dynamics, cell attachment and migration, and local cell–cell interactions. Such an integrated perspective of these key aspects will be critical to open up new directions in tissue engineering research, as significant progress can be made by combining existing computational and experimental methods. Furthermore, theoretical modelling has enormous potential in applications ranging from the interpretation of experimental results and the identification of the main governing processes, to the optimization of practical tissue engineering protocols with implications therein for an increasing ageing population.

Keywords
Bone tissue engineering; Cartilage tissue engineering; Modelling; Cell proliferation; Cell spreading; Extracellular matrix
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Computational modelling of cell spreading and tissue regeneration in porous scaffolds
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 10, April 2007, Pages 1926–1940
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us