fulltext.study @t Gmail

The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption

Paper ID Volume ID Publish Year Pages File Format Full-Text
10382 683 2009 7 PDF Available
Title
The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption
Abstract

Amphiphilic PEO–silanes (a–c) having siloxane tethers of varying lengths with the general formula α-(EtO)3Si–(CH2)2–oligodimethylsiloxanen-block-poly(ethylene oxide)8–OCH3 [n = 0 (a), n = 4 (b), and n = 13 (c)] were grafted onto silicon wafers and resistance to adsorption of plasma proteins was measured. Distancing the PEO segment from the hydrolyzable triethoxysilane [(EtO)3Si] grafting group by a oligodimethylsiloxane tether represents a new method of grafting PEO chains to surfaces. Properties of surfaces grafted with a–c were compared to surfaces grafted with a traditional PEO–silane containing a propyl spacer [(EtO)3Si–(CH2)3–poly(ethylene oxide)8–OCH3, PEO control]. As the siloxane tether length increased, chain density of PEO–silanes grafted onto oxidized silicon wafers decreased and hydrophobicity of the PEO–silane increased which led to a decrease in surface hydrophilicity. Despite decreased surface hydrophilicity, resistance to the adsorption of bovine serum albumin (BSA) increased in the order: PEO control < a < b ≈ c and to human fibrinogen (HF) increased in the order: PEO control < a < b < c.

Keywords
Polyethylene oxide; Siloxane; Protein adsorption; Surface grafting
First Page Preview
The influence of poly(ethylene oxide) grafting via siloxane tethers on protein adsorption
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 13, May 2009, Pages 2433–2439
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us