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A novel drug vehicle capable of ultrasound-triggered release with MRI functions

Paper ID Volume ID Publish Year Pages File Format Full-Text
1039 72 2011 8 PDF Available
Title
A novel drug vehicle capable of ultrasound-triggered release with MRI functions
Abstract

A novel remotely triggered drug vehicle, magnetic hydroxyapatite (HA)-coated liposome (i.e. HA-coated liposome decorated with superparamagnetic iron oxide (SPIO) nanodots; HA/SPIO-coated liposome), was developed to exhibit ultrasound-triggered release behavior, magnetic resonance imaging (MRI) contrast and ultrasound-induced MRI contrast change. In this study, the effects of the HA/SPIO coating layer on the background leakage, response to ultrasound and MR signal were investigated. The background leakage of the liposome was significantly reduced due to HA/SPIO coating of the liposome. This coating layer also enhanced the sensitivity of the drug vehicle to ultrasound under sonication conditions at high frequencies (1 and 3 MHz) and low power densities (0.2–0.4 W cm−2). Moreover, the ultrasound-triggered vehicle exhibited a concentration-dependent T2 (spin–spin relaxation time) contrast in MR images due to their decoration with SPIO nanodots. In addition, r2 and r2∗ (transverse relaxivity) values increased with increasing amounts of SPIO decoration, suggesting that the MR images of HA/SPIO-coated liposomes could be probed by the T2 signal. Most importantly, the r2∗-r2 value of HA/SPIO-coated liposomes decreased after sonication, which was more prominent for the sample with lower SPIO amounts. This suggests that this novel drug vehicle can be used not only as an MR image-guided drug vehicle capable of ultrasound-triggered release, but also as an MR reporter to probe the status of vehicles after ultrasonic triggering.

Keywords
Ultrasound-triggered release; MR image; SPIO; Hydroxyapatite; Liposome
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A novel drug vehicle capable of ultrasound-triggered release with MRI functions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 11, November 2011, Pages 3927–3934
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us