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Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections

Paper ID Volume ID Publish Year Pages File Format Full-Text
10395 683 2009 7 PDF Available
Title
Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections
Abstract

Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) decreases following major injuries resulting in decreased cell-mediated immune response. Here we report the development of IL-12 nanoscale coatings using electrostatic layer-by-layer self-assembly nanotechnology. We found that IL-12 nanoscale coatings at the implant/tissue interface substantially decrease infections in vivo, and IL-12 nanoscale coatings are advantageous over traditional treatments. This approach could be a revolutionary step toward preventing device-associated infections using a non-antibiotic approach.

Keywords
Antimicrobial; Bone; Cytokine; Drug delivery; Infection; Surface modification
First Page Preview
Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 13, May 2009, Pages 2552–2558
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering