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Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
10458 685 2007 9 PDF Available
Title
Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells
Abstract

A tissue-engineered adipose substitute would have numerous applications in plastic and reconstructive surgery. This work involves the characterization of the in vitro cellular response of primary human adipose-derived stem cells (ASC) to three dimensional, naturally derived scaffolds. To establish a more thorough understanding of the influence of the scaffold environment on ASC, we have designed several different soft tissue scaffolds composed of decellularized human placenta and crosslinked hyaluronan (XLHA). The cellular organization within the scaffolds was characterized using confocal microscopy. Adipogenic differentiation was induced and the ASC response was characterized in terms of glycerol-3-phosphate dehydrogenase (GPDH) activity and intracellular lipid accumulation. The results indicate that the scaffold environment impacts the ASC response and that the adipogenic differentiation of the ASC was augmented in the non-adhesive XLHA gels.

Keywords
Adipose tissue engineering; Scaffold; Extracellular matrix; Hyaluronan; Stem cells
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Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 26, September 2007, Pages 3834–3842
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us