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The effect of a layer-by-layer chitosan–heparin coating on the endothelialization and coagulation properties of a coronary stent system

Paper ID Volume ID Publish Year Pages File Format Full-Text
10512 688 2009 8 PDF Available
Title
The effect of a layer-by-layer chitosan–heparin coating on the endothelialization and coagulation properties of a coronary stent system
Abstract

A biomacromolecular layer-by-layer coating process of chitosan/heparin onto a coronary stent is designed for the acceleration of the re-endothelialization and healing process after coronary stent deployment. The results of in vitro culturing of porcine iliac artery endothelial cells as well as the measurements of the APTT, PT and TT supported the rationale that the combination of chitosan and heparin could bring both endothelial cell compatibility and haemocompatibility to the stent surface. A porcine coronary injury model and arteriovenous shunt model were used for the further evaluation of the application of this kind of surface-modified stainless steel stent in vivo. The final results proved that this facile coating approach could significantly promote re-endothelialization and was safer compared with bare metal stents for its much improved anticoagulation property.

Keywords
Stent; Haemocompatibility; Endothelialization; Self assembly
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The effect of a layer-by-layer chitosan–heparin coating on the endothelialization and coagulation properties of a coronary stent system
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 12, April 2009, Pages 2276–2283
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us