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Convection-enhanced delivery of nanocarriers for the treatment of brain tumors

Paper ID Volume ID Publish Year Pages File Format Full-Text
10515 688 2009 17 PDF Available
Title
Convection-enhanced delivery of nanocarriers for the treatment of brain tumors
Abstract

Primary brain tumors have a significant infiltrative capacity as their reappearance after resection usually occurs within 2 cm of the tumor margin. Local delivery method such as Convection-Enhanced Delivery (CED) has been introduced to avoid this recurrence by delivering active molecules via positive-pressure methods. For an efficient infusion, the distribution volume of the drug has to be optimized while avoiding backflow, since this is responsible for side effects and a reduction of therapeutic efficacy. The encapsulation of the drug infused in nanosized structures can be considered, which would lead to a reduction of both toxicity of the treatment and infusion time during CED. In the present review, we will firstly discuss the technical approach of CED with regard to catheter design and brain characteristics; secondly, we will describe the ‘ideal’ nanocarrier in terms of size, surface properties, and interaction with the extracellular matrix for optimal diffusion in the brain parenchyma. We also discuss preclinical and clinical applications of this new method.

Keywords
Brain tumor; Convection-enhanced delivery; Backflow; Distribution volume; Nanocarrier; Anticancer treatment
First Page Preview
Convection-enhanced delivery of nanocarriers for the treatment of brain tumors
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 12, April 2009, Pages 2302–2318
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering