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Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines

Paper ID Volume ID Publish Year Pages File Format Full-Text
10529 689 2006 8 PDF Available
Title
Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines
Abstract

Porous carbons can be used for the purification of various bio-fluids, including the cleansing blood of inflammatory mediators in conditions such as sepsis or auto-immune diseases. Here we show that the control of pore size in carbons is a key factor to achieving efficient removal of cytokines. In particular, the surface area accessible by the protein governs the rate and effectiveness of the adsorption process. We demonstrate that novel mesoporous carbon materials synthesized from ternary MAX-phase carbides can be optimized for efficient adsorption of large inflammatory proteins. The synthesized carbons, having tunable pore size with a large volume of slit-shaped mesopores, outperformed all other materials or methods in terms of efficiency of TNF-α removal and the results are comparable only with highly specific antibody–antigen interactions.

Keywords
Carbon; Protein adsorption; Adsorption; Cytokine
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Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 34, December 2006, Pages 5755–5762
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us