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A 12 month in vivo study on the response of bone to a hydroxyapatite–polymethylmethacrylate cranioplasty composite

Paper ID Volume ID Publish Year Pages File Format Full-Text
10563 691 2007 6 PDF Available
Title
A 12 month in vivo study on the response of bone to a hydroxyapatite–polymethylmethacrylate cranioplasty composite
Abstract

We investigated the osteoconductivity and biocompatibility in vivo of a new hydroxyapatite–polymethylmethacrylate (HA–PMMA) composite developed for use as an implant material for cranioplasty, which is expected to have the good osteoconductivity of HA together with the strength and ease of handling of PMMA. The HA–PMMA composites were implanted in eight full-grown beagles and then 6, 12, 24 weeks and 1 year after implantation, the animals were sacrificed and the implanted materials removed along with the surrounding tissues. Extirpated specimens were studied using an optical microscope and micro-computed tomography (micro-CT). Fibrous connective tissue was prominent in the interface of the composite at 6 weeks. New bone formation was seen around the implant, 12 and 24 weeks after operation. At 1 year, new bone filled in the interface of the HA–PMMA composite and adhered to the surrounding autogenous bone. Mixing HA and PMMA did not interfere with the osteoconductivity of the HA component. In micro-CT findings, the new bone growing on the HA–PMMA composite could be seen attaching preferentially to HA particles exposed at the composite surface, rather than the PMMA. This study demonstrated that this HA–PMMA composite is a good candidate for cranial bone implants due to its good osteoconductivity and biocompatibility.

Keywords
Hydroxyapatite–polymethylmethacrylate composite; Osteoconductivity; Biocompatibility; Cranioplasty; In vivo
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A 12 month in vivo study on the response of bone to a hydroxyapatite–polymethylmethacrylate cranioplasty composite
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 33, November 2007, Pages 4922–4927
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us