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Active targeting of brain tumors using nanocarriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
10566 691 2007 21 PDF Available
Title
Active targeting of brain tumors using nanocarriers
Abstract

The delivery of drugs to brain tumors is limited by the presence of the blood–brain barrier (BBB) separating the blood from the cerebral parenchyma. An understanding of the specific mechanisms of the brain capillary endothelium has led to the development of various strategies to enhance the penetration of drugs into the brain tissue. Active targeting is a non-invasive approach, which consists in transporting drugs to target organs using site-specific ligands. Drug-loaded nanocarriers capable of recognizing brain capillary endothelial cells and cerebral tumoral cells have shown promising potential in oncology. Endogenous and chimeric ligands binding to carriers or receptors of the BBB have been directly or indirectly conjugated to nanocarriers. This review indexes the main targeted colloidal systems used for drug delivery to the brain. Their pharmacological behavior and their therapeutic effect are discussed.

Keywords
Nanocarriers; Active targeting; Brain tumors; Endogenous ligands; Monoclonal antibodies; Receptor-mediated transcytosis5-FU, 5-fluorouracil; ABC, ATP-binding cassette; AME, adsorptive-mediated endocytosis; APO, apolipoproteins; BBB, blood–brain barrier; B
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Active targeting of brain tumors using nanocarriers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 33, November 2007, Pages 4947–4967
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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