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In vitro evaluation of a poly(lactide-co-glycolide)–collagen composite scaffold for bone regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
10586 692 2006 7 PDF Available
Title
In vitro evaluation of a poly(lactide-co-glycolide)–collagen composite scaffold for bone regeneration
Abstract

Numerous materials have been proposed for bone tissue regeneration. However, none has been shown to be entirely satisfactory. In this study we fabricated a hybrid composite scaffold composed of poly(d,l-lactide-co-glycolide) (PLGA) and a naturally derived collagen matrix derived from porcine bladder submucosa matrix (BSM), and evaluated the biological activities and physical properties of the scaffold for use in bone tissue regeneration. The BSM–PLGA composite scaffolds are able to promote cellular interactions and possess uniformly interconnected pores with adequate structural integrity. The composite scaffolds were tested with both human embryonic stem (hES) cells and bovine osteoblasts (bOB). Cells seeded on the composite scaffolds readily attached, infiltrated and proliferated, as confirmed by cell viability and mitochondrial metabolic activity. Use of the composite scaffolding system with cells may enhance the formation of bone tissue for therapeutic regeneration.

Keywords
Bladder submucosa matrix; Poly(d,l-lactide-co-glycolide); Scaffold; Bone tissue regeneration
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In vitro evaluation of a poly(lactide-co-glycolide)–collagen composite scaffold for bone regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 18, June 2006, Pages 3466–3472
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us