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Osteotropic β-cyclodextrin for local bone regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
10623 694 2008 7 PDF Available
Title
Osteotropic β-cyclodextrin for local bone regeneration
Abstract

An osteotropic alendronate-β-cyclodextrin conjugate (ALN-β-CD) was developed as a bone-targeting delivery system for improved treatment of skeletal diseases. The conjugate shows very strong binding to hydroxyapatite (HA, main component of the skeleton). Its ability in forming molecular inclusion complex with prostaglandin E1 (PGE1, a potent bone anabolic agent) was confirmed by phase solubility experiments and differential scanning calorimetry (DSC). In a bilateral rat mandible model, ALN-β-CD/PGE1 molecular complex was shown to stimulate strong local bone anabolic reaction. In the control study, ALN-β-CD itself was also found to be bone anabolic. To investigate this finding, other control groups were studied. The histomorphometry data suggest that ALN-β-CD itself could generate more new bone at the injection site than its complex with PGE1. Alendronate (ALN) injection could also cause new bone formation, which locates peripheral to the site of injection. PGE1, saline or ethanol injections do not have anabolic effect. These findings were also confirmed by micro-CT evaluation of mandibular bones. It is clear that the bone anabolic effect of ALN-β-CD is independent of mechanical stimuli of the periosteum or ALN injection alone. Further studies are warranted to understand the working mechanism of ALN-β-CD as a bone anabolic agent.

Keywords
Bone regeneration; Osteoporosis; Hydroxyapatite; Drug deliveryALN, alendronate; ALN-β-CD, alendronate-β-cyclodextrin conjugate; β-CD, β-cyclodextrin; DSC, differential scanning calorimetry; EDC, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride
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Osteotropic β-cyclodextrin for local bone regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 11, April 2008, Pages 1686–1692
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us