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Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute

Paper ID Volume ID Publish Year Pages File Format Full-Text
10624 694 2008 12 PDF Available
Title
Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute
Abstract

There is a huge clinical demand for Human Serum Albumin (HSA), with a world market of ∼$1.5B/year. Concern over prion and viral transmission in the blood supply has led to a need for safer substitutes and offers the opportunity for development of materials with enhanced properties over the presently available plasma expanders. We report here the synthesis and testing of a new synthetic plasma expander that can replace not only the osmotic and volume expansion properties of HSA but, uniquely, its binding and transport properties. We have synthesized several hyperbranched polyglycerols derivatized with hydrophobic groups and short poly(ethylene glycol) (PEG) chains. The hydrophobic groups provide regions for binding fatty acids and other hydrophobic materials while PEG imparts the necessary protection from host defense systems and enhances circulation longevity. These polymers, being hyperbranched, have only a small effect on plasma viscosity. We have shown in vitro that our materials bind 2–3 moles palmitic acid per mole, do not activate the platelet, coagulation or complement systems and do not cause red cell aggregation. In mice these materials are non-toxic with circulation half-lives as high as 34 h, controllable by manipulating the molecular weight and the degree of PEG derivatization.

Keywords
Plasma expander; Albumin substitute; Biocompatibility; Hyperbranched polyglycerols; Poly(ethylene glycol); Animal toxicity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 11, April 2008, Pages 1693–1704
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us