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The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model

Paper ID Volume ID Publish Year Pages File Format Full-Text
10628 694 2008 7 PDF Available
Title
The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model
Abstract

An in vivo study was carried out on uncoated and hydroxyapatite (HA)-coated nanostructured Ti13Nb11Zr alloy in comparison with high-grade Ti6Al4V, to investigate the effect of the different surfaces on osteointegration rate. A highly effective method to obtain a fast biomimetic deposition of a thin layer of nanocrystalline HA was applied to coat both substrates. Cylindrical pins were implanted in rabbit cortical bone and evaluated at 4 and 12 weeks by histomorphometry and microhardness tests. The results confirmed the ability of the slightly supersaturated Ca/P solution to induce a fast deposition of nanocrystalline HA on Ti alloys' surfaces. HA-coated Ti13Nb11Zr had the highest osteointegration rate at 4 and 12 weeks. Both HA-coated surfaces showed an affinity index significantly higher than those of native surfaces at 4 weeks (Ti13Nb11Zr + HA: 37%; Ti6Al4V + HA: 26%). Microhardness test showed a significantly higher bone mineralization index of HA-coated Ti13Nb11Zr in comparison with that of HA-coated Ti6Al4V surface. The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti–Nb–Zr alloy with the HA coating on bone remodeling and maturation.

Keywords
Titanium alloys; Niobium; Biomimetic material; Hydroxyapatite; Osteointegration
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The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 11, April 2008, Pages 1730–1736
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us