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The effect of discrete calcium phosphate nanocrystals on bone-bonding to titanium surfaces

Paper ID Volume ID Publish Year Pages File Format Full-Text
10644 696 2007 8 PDF Available
Title
The effect of discrete calcium phosphate nanocrystals on bone-bonding to titanium surfaces
Abstract

We sought to address the question: Can metallic surfaces be rendered bone-bonding? We employed dual acid-etched (DAE) commercially pure titanium (cpTi) and titanium alloy (Ti6Al4V) custom-made rectangular coupons (1.3 mm×2.5 mm×4 mm) with, or without, further modification by the discrete crystalline deposition (DCD) of calcium phosphate (CAP) nanocrystals. A total of 48 implants comprising four groups were placed bilaterally in the distal femur of male Wistar rats for 9 days. After harvesting, the bone immediately proximal and distal to the implant was removed, resulting in a test sample comprising the implant with two attached cortical arches. The latter were distracted at 30 mm/min, in an Instron™ machine, and the disruption force was recorded. Results showed that alloy samples exhibited greater disruption forces than cpTi, and that DCD samples had statistically significantly greater average disruption forces than non-DCD samples. The bone-bonding phenomenon was visually evident by fracture of the cortical arches and an intact bone/implant interface. Field emission scanning electron microscopy showed the bone/implant interface was occupied by a bony cement line matrix that was interlocked with the surface topographical features of the implant. We conclude that titanium implant surfaces can be rendered bone-bonding by an increase in the complexity of the surface topography.

Keywords
Bone-bonding; Titanium; Titanium alloy; Calcium phosphate; Mechanical test
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The effect of discrete calcium phosphate nanocrystals on bone-bonding to titanium surfaces
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 32, November 2007, Pages 4748–4755
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us