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Oxygen producing biomaterials for tissue regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
10668 697 2007 7 PDF Available
Title
Oxygen producing biomaterials for tissue regeneration
Abstract

A limiting factor in regenerating large organs and healing large wounds completely is the inability to provide oxygen to the affected areas for vascularization and healing to occur. An oxygen rich compound of sodium percarbonate was incorporated into films of Poly(d,l-lactide–co–glycolide) (PLGA) and used for in situ production of oxygen. Oxygen release could be observed from the film over a period of 24 h. When the oxygen producing biomaterials were placed in contact with ischemic tissue in a mouse model, decreased tissue necrosis and cellular apoptosis was observed. This indicates that improved tissue viability could be maintained for several days using oxygen producing biomaterials.

Keywords
Oxygenation; Fibroblasts; Hypoxia; Controlled drug release; Tissue engineering
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Oxygen producing biomaterials for tissue regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 31, November 2007, Pages 4628–4634
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us