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Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly

Paper ID Volume ID Publish Year Pages File Format Full-Text
10674 697 2007 9 PDF Available
Title
Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly
Abstract

DNA vaccination has tremendous potential for treating or preventing numerous diseases for which traditional vaccines are ineffective but the technique can be limited by low immunogenicity. Current synthetic DNA delivery systems are versatile and safe, but substantially less efficient than viruses. Here, a novel multicomponent supramolecular system involving the preparation of mannose-bearing chitosan oligomers microspheres with entrapping complexes of DNA vaccine and polyethylenimine was developed to mimic many of the beneficial properties of the viruses. After delivery by intramuscular immunization in BALB/c mice, the microspheres induced an enhanced serum antibody responses two orders of magnitude greater than naked DNA vaccine. Additionally, in contrast to naked DNA, the microspheres induced potent cytotoxic T lymphocyte responses at a low dose. Consequently, formulation of DNA vaccines into multicomponent vectors is a powerful means of increasing vaccine potency.

Keywords
Mannose-bearing Chitosan oligomers microspheres; Supramolecular assembly; DNA vaccine; Artificial virus; ImmunogenicityMBCO microspheres, mannose-bearing chitosan oligomers microspheres; PEI, polyethylenimine; CTL, cytotoxic T lymphocyte; i.m., intramuscu
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Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 31, November 2007, Pages 4684–4692
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us