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Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
10702 699 2006 5 PDF Available
Title
Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible ☆
Abstract

In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.

Keywords
In vivo tissue engineering; Bone regeneration; Replacement; Bioreactor; Mandible reconstruction; BMP
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Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 17, June 2006, Pages 3163–3167
Authors
, , , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us