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Influence of the zinc concentration of sol–gel derived zinc substituted hydroxyapatite on cytokine production by human monocytes in vitro

Paper ID Volume ID Publish Year Pages File Format Full-Text
10706 699 2006 6 PDF Available
Title
Influence of the zinc concentration of sol–gel derived zinc substituted hydroxyapatite on cytokine production by human monocytes in vitro
Abstract

A possible complication associated with the implantation of hydroxyapatite (HA)-based prosthesis is the release of particles. These particles can be phagocyted by monocytes that are among the first cells to colonize the inflammatory site. The activated monocytes produce inflammatory mediators such as cytokines that cause osteoclasts activation. The present work, describes studies on the effect of sol–gel derived zinc-substituted HA particles with various zinc substitution percentages (0.5–2%) on cytokine production (TNF-α, IL-1β, IL-6, IL-10, and IL-8) by both LPS-stimulated or unstimulated human monocytes. Our data demonstrates that the zinc has an effect on cytokines production. It decreases the production of TNF-α and increases the production of IL-8 by unstimulated cells. Using LPS-stimulated cells, it decreases the production of inflammatory cytokines and increases the production of anti-inflammatory cytokine (IL-10), indicating that zinc-substituted hydroxyapatite has favourable effects on the cytokines production by monocytes.

Keywords
Hydroxyapatite particles; Cytokines; Inflammation; Zinc; Monocytes
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Influence of the zinc concentration of sol–gel derived zinc substituted hydroxyapatite on cytokine production by human monocytes in vitro
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 17, June 2006, Pages 3195–3200
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us