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Interaction of dermal fibroblasts with electrospun composite polymer scaffolds prepared from dextran and poly lactide-co-glycolide

Paper ID Volume ID Publish Year Pages File Format Full-Text
10708 699 2006 12 PDF Available
Title
Interaction of dermal fibroblasts with electrospun composite polymer scaffolds prepared from dextran and poly lactide-co-glycolide
Abstract

A highly porous electrospun scaffold was prepared by physically blending Dextran and poly lactide-co-glycolide (PLGA). The interaction between dermal fibroblasts and the Dextran/PLGA scaffold such as viability, proliferation, attachment, migration, extracellular matrix deposition, cytoskeleton organization and the functional gene expressions were characterized. The results indicated that cells interacted favorably with the scaffold. Moreover, cells migrated into the highly porous three dimensional matrix of the scaffold and organized into dense multi-layered structures that resembled dermal structure. The results of collagen gel assay also revealed that gel contraction was enhanced by the presence of the scaffold. The additional mechanical strength provided by the scaffold could enhance the binding of the seeded fibroblasts. These findings suggested that Dextran/PLGA scaffold can potentially be useful in enhancing the healing of chronic or trauma wounds.

Keywords
Bioactivity; Cell culture; Fibroblast; Dextran; Polyglycolic acid; Polylactic acid
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Interaction of dermal fibroblasts with electrospun composite polymer scaffolds prepared from dextran and poly lactide-co-glycolide
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 17, June 2006, Pages 3209–3220
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us