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The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution

Paper ID Volume ID Publish Year Pages File Format Full-Text
10717 699 2006 9 PDF Available
Title
The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution
Abstract

A percutaneous device with antibacterial activity and good biocompatibility is desired for clinical applications. Three types of antibacterial agent: lactoferrin (LF), tetracycline (TC), and gatifloxacin (GFLX) were immobilized on the surface of an ethylene-vinyl alcohol copolymer (EVOH) using a liquid phase coating process. In this process, an EVOH plate was alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable calcium phosphate solution supplemented with 4, 40, or 400 μg/mL of the antibacterial agent. As a result, the antibacterial agent was immobilized on the EVOH surface in the form of an antibacterial agent–apatite composite layer. The amount of immobilized antibacterial agent increased with increasing absorption affinity for apatite in the order: GFLX

Keywords
Apatite; Antibacterial agent; Lactoferrin (LF); Tetracycline (TC); Gatifloxacin (GFLX); Percutaneous device
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The formation of an antibacterial agent–apatite composite coating on a polymer surface using a metastable calcium phosphate solution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 17, June 2006, Pages 3295–3303
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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