fulltext.study @t Gmail

Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture

Paper ID Volume ID Publish Year Pages File Format Full-Text
10766 702 2006 7 PDF Available
Title
Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture
Abstract

Recently [Jessel N, Schwinte P, Donohue R, Lavalle P, Boulmedais F, Darcy R, et al. Pyridylamino-β-cyclodextrin as a molecular chaperone for lipopolysaccharide embedded in a multilayered polyelectrolyte architecture. Adv Funct Mater 2004;14:963–9], we demonstrated the biological activity of a lipopolysaccharide from Escherichia coli incorporated into layer-by-layer films made of poly (l-lysine) and poly (l-glutamic acid) and containing a polycationic β-cyclodextrin (CD) with chaperone properties. Here we develop innovative architectures containing a complex made of a charged β-cyclodextrin and a lipid A antagonist (LAA) as potential systems for local endotoxin antagonistic activity. We examine the biological activity of these architectures. The CD–LAA complex adsorbed on top, or embedded into the polyelectrolyte films keeps its LPS antagonistic activity on both murine and human macrophages for at least 24 h.

Keywords
Layer-by-layer films; Anti-inflammatory activity; Lipid A antagonist; Cyclodextrin
First Page Preview
Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 9, March 2006, Pages 1771–1777
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us