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A method for solvent-free fabrication of porous polymer using solid-state foaming and ultrasound for tissue engineering applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
10784 702 2006 6 PDF Available
Title
A method for solvent-free fabrication of porous polymer using solid-state foaming and ultrasound for tissue engineering applications
Abstract

Most of the existing fabrication techniques for tissue engineering scaffolds require the use of organic solvents that may never be fully removed even after long leaching hours. The residues of these organic solvents reduce the ability of biological cells to form new tissue. This paper presents an approach toward solvent-free fabrication of tissue engineering scaffolds. Interconnected porous structures were created using solid-state foaming and ultrasound. The material used in this study was polylactic acid (PLA) and the blowing agent was CO2. In order to determine suitable process conditions, saturation and foaming studies were first conducted. Selected foam samples were then processed using pulsed ultrasound. The microstructures before and after the ultrasound processing were compared. It was shown that the inter-pore connectivity of the solid-state foams was substantially enhanced. The combined solid-state foaming and ultrasound processing provide a way to fabricate porous polymer for potential tissue engineering applications.

Keywords
Solvent-free fabrication; Tissue engineering scaffold; Polylactic acid (PLA); Ultrasound; Solid-state foams; Porous polymer
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A method for solvent-free fabrication of porous polymer using solid-state foaming and ultrasound for tissue engineering applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 9, March 2006, Pages 1924–1929
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us