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Preparation, physical–chemical characterisation and cytocompatibility of calcium carbonate cements

Paper ID Volume ID Publish Year Pages File Format Full-Text
10787 702 1954 10 PDF Available
Title
Preparation, physical–chemical characterisation and cytocompatibility of calcium carbonate cements
Abstract

The feasibility of calcium carbonate cements involving the recrystallisation of metastable calcium carbonate varieties has been demonstrated. Calcium carbonate cement compositions presented in this paper can be prepared straightforwardly by simply mixing water (liquid phase) with two calcium carbonate phases (solid phase) which can be easily obtained by precipitation. An original cement composition was obtained by mixing amorphous calcium carbonate and vaterite with an aqueous medium. The cement set and hardened within 2 h at 37 °C in an atmosphere saturated with water and the final composition of the cement consisted mostly of aragonite. The hardened cement was microporous and showed poor mechanical properties. Cytotoxicity tests revealed excellent cytocompatibility of calcium carbonate cement compositions. Calcium carbonates with a higher solubility than the apatite formed for most of the marketed calcium phosphate cements might be of interest to increase biomedical cement resorption rates and to favour its replacement by bone tissue.

Keywords
Bone cement; Calcium carbonate; Aragonite; FTIR spectroscopy; Cytotoxicity
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Preparation, physical–chemical characterisation and cytocompatibility of calcium carbonate cements
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 27, Issue 9, March 2006, Pages 1945–1954
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
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