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The molecular structure of complexes formed by chromium or cobalt ions in simulated physiological fluids

Paper ID Volume ID Publish Year Pages File Format Full-Text
10818 703 2009 8 PDF Available
Title
The molecular structure of complexes formed by chromium or cobalt ions in simulated physiological fluids
Abstract

It is well recognized that workers in mines and manufacturers of hard metals in contact with metal ions have increased risk of cancer. However, the various chemical forms of these ions in living organisms are not well characterized, and little is known of how they interact with biological environments. Here, we sought to elucidate the molecular structures formed by cobalt (Co) and chromium (Cr) ions in simulated biological fluids. Transmission electron microscopy observations revealed that Cr(III) formed nanoscale complexes which precipitate in both RPMI 1640 and DMEM high glucose media. However, no complexes were observed with Co(II) and Cr(VI). Energy-dispersive X-ray analysis, elemental analysis, and Fourier transform infrared (FT-IR) spectroscopy indicated that Cr(III) ions act as chelating entities between PO4 groups, amino acids, and calcium. Although the exact nature of the bonds remains to be investigated, the presence of PO4 may favor the formation of low energy hydrogen bonds. Interestingly, the nature of amino acids varied in Cr(III) complexes formed in RPMI 1640 compared to those formed in DMEM high glucose. The absence of sulphur in the elemental analysis spectrum suggested that methionine and cystine, two amino acids containing sulphur, are not involved in the formation of Cr(III) complexes. Thus, the lower toxicity of Cr(III) compared to Co(II) and Cr(VI) may be related to the formation of these chemical complexes. These results may bring some insight in understanding the relationship between toxicity and the chelating capabilities of various metal ions in vitro and in vivo.

Keywords
Chromium; Cobalt; Toxicity; Molecular interactions; Simulated physiological fluids; Nanoscale complexes
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The molecular structure of complexes formed by chromium or cobalt ions in simulated physiological fluids
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 4, February 2009, Pages 460–467
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us