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Controlled remineralization of enamel in the presence of amelogenin and fluoride

Paper ID Volume ID Publish Year Pages File Format Full-Text
10820 703 2009 6 PDF Available
Title
Controlled remineralization of enamel in the presence of amelogenin and fluoride
Abstract

Reconstructing enamel-like structures on teeth have been an important topic of study in the material sciences and dentistry. The important role of amelogenin in modulating the mineralization of organized calcium phosphate crystals has been previously reported. We used amelogenin and utilized a modified biomimetic deposition method to remineralize the surface of etched enamel to form mineral layers containing organized needle-like fluoridated hydroxyapatite crystals. The effect of a recombinant amelogenins (rP172) on the microstructure of the mineral in the coating was analyzed by SEM, XRD and FT-IR. At rP172 concentrations below 33 μg/mL, no significant effect was observed. In the presence of 1 mg/L F and at a concentration of 33 μg/mL rP172, formation of fused crystals growing from the enamel surface was initiated. Amelogenin promoted the oriented bundle formation of needle-like fluoridated hydroxyapatite in a dose dependent manner. Biomimetic synthesis of the amelogenin fluoridated hydroxyapatite nano-composite is one of the primary steps towards the development and design of novel biomaterial for future application in reparative and restorative dentistry.

Keywords
Amelogenin; Fluoride; Enamel remineralization; Fluoridated hydroxyapatite
First Page Preview
Controlled remineralization of enamel in the presence of amelogenin and fluoride
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 4, February 2009, Pages 478–483
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering