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Enamel inspired nanocomposite fabrication through amelogenin supramolecular assembly

Paper ID Volume ID Publish Year Pages File Format Full-Text
10870 705 2007 9 PDF Available
Title
Enamel inspired nanocomposite fabrication through amelogenin supramolecular assembly
Abstract

Fabricating the structures similar to dental enamel through the in vitro preparation method is of great interest in the fields of dentistry and material sciences. Developing enamel is composed of calcium phosphate mineral, water, and enamel matrix proteins, mainly amelogenins. To prepare a material mimicking such composition a novel approach of simultaneously assembling amelogenin and calcium phosphate precipitates by electrolytic deposition (ELD) was established. It was found that recombinant full-length amelogenin (rP172) self-assembled into nanochain structures during ELD (following increase in solution pH), and had significant effect on the induction of the parallel bundles of calcium phosphate nanocrystals, grown on semiconductive silicon wafer surface. When a truncated amelogenin (rP148) was used; no nanochain assembly was observed, neither parallel bundles were formed. The coating obtained in the presence of rP172 had improved elastic modulus and hardness when compared to the coating incorporated with rP148. Our data suggest that the formation of organized bundles in amelogenin–apatite composites is mainly driven by amelogenin nanochain assembly and highlights the potential of such composite for future application as dental restorative materials.

Keywords
Electrolytic deposition; Amelogenin; Self-assembly; Enamel; Nanoindentation; Elastic modulus
First Page Preview
Enamel inspired nanocomposite fabrication through amelogenin supramolecular assembly
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 28, Issue 19, July 2007, Pages 3034–3042
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering