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Impact of heat on nanocrystalline silver dressings: Part I: Chemical and biological properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
10892 707 2005 9 PDF Available
Title
Impact of heat on nanocrystalline silver dressings: Part I: Chemical and biological properties
Abstract

Thermal stability of heat-treated nanocrystalline silver dressings was investigated using chemical techniques and biological assays. Dressings were heat-treated for 24 h at temperatures from 23 to 110 °C. Bactericidal efficacy of heat-treated dressings was measured using a log reduction assay, while antibacterial longevity was determined via plate-to-plate transfer corrected zone of inhibition assays. Over the temperature range tested, biological activity dropped from excellent to negligible. Biological longevity results showed that controlled release properties of the dressings were significantly reduced by heat treatments above 75 °C. These data illustrate nanocrystalline silver sensitivity to heat. Further, it was clear that dressing efficacy is determined by total available soluble silver, not total silver in the dressing. It was determined that the quantity of soluble silver decreased significantly with increased heat treatment temperatures. These results should be considered in developing new nanocrystalline drug delivery systems.

Keywords
Antibacterial; Antimicrobial; Bioactivity; In vitro test; Nanocrystalline; Silver
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Impact of heat on nanocrystalline silver dressings: Part I: Chemical and biological properties
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 35, December 2005, Pages 7221–7229
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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