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Effect of processing route and acetone pre-treatment on the biostability of pellethane materials used in medical device applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
10966 711 2005 10 PDF Available
Title
Effect of processing route and acetone pre-treatment on the biostability of pellethane materials used in medical device applications
Abstract

Thermoplastic polyurethanes, such as Pellethane 2363 80A™ (Pel80A) and Pellethane 2363 55D™ (Pel55D) are widely used in the medical device industry because of their biological and mechanical properties. However, premature failure in such devices has been observed and attributed to environmental stress cracking (ESC). The current work investigates the possibility of reducing ESC via bulk morphology manipulation. This can be achieved through various processing routes such as solvent-casting (SC) and hot-press quenching (HPQ). The effect of stress on the bulk morphology of Pel55D and Pel80A was evaluated using small-angle X-ray scattering (SAXS) in conjunction with tensile testing. SC samples exhibited greater phase separation compared with HPQ samples. Alignment of hard segment domains became apparent around the point of yield. Onset of ESC with respect to SC and HPQ routines was determined using the Zhao–Stokes glass-wool test with optical (OM) and environment scanning electron microscopy (ESEM). Improvement in biostability of Pel80A was found in HPQ samples compared to those that were SC. A secondary objective of this work was to investigate the effect of acetone pre-treatment on surface morphology. High resolution imaging of acetone treated and untreated SC Pel80A showed significant differences in surface morphology.

Keywords
Polyurethane; Biocompatibility; Haemocompatibility; Oxidation
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Effect of processing route and acetone pre-treatment on the biostability of pellethane materials used in medical device applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 33, November 2005, Pages 6467–6476
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us